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During the last 5 years, RRL has literally metamorphised into a modernised research Institution with focused goals. For fruitful existence we opened up, first at national level and then at International level. Now we are focused and working on the areas of science, which are not only relevant to India but are also globally acceptable and welcomed for the well being of the people. During these years, RRL has been able to attract the attention of large number of Industries and is delivering to their expectations.
Dr.G.N.Qazi
(Director, RRL)
Technologies Transferred : 
End to end technology package of Hypericum perforatum ( St. John's Wort): In a very short period, complete protocol for its micropropagation, agrotechno logical package, chemical standardization on the basis of two major molecules - hypericin and hyperforin and six minor compounds has been developed. The drug thus standerdised on the basis of HPLC and LCMS n conform to the US pharmacopoeial standards with hypericin ( upto 0.3%) and hyperforin ( > 3%). In comparison, the other commercially available preparations of H. perforatum on Indian market were found to contain hypericin, but the hyperforin (most important ingredent) content was found to be nil to negligible in almost all the tested samples.
These marker molecules are now available with us in large quantities. Earlier, these molecules were only available at exorbitant costs with a couple of companies world over.
The entire work on Hypericum was supported by Nicholas Piramal Group and the formulation conforming to USP has been developed by us for this company for captive and International market.
Natural Calicitriol : A drug for skin diseases : Calicitriol, physiologically active form of Vitamin D3 plays an important role in influencing the calcium uptake in intestine and bones. The drug is used for the prevention of osteoporosis and skin disorders like psoriasis. The natural drug is present in traces in a plant source. RRL, Jammu has developed an efficient and novel process to enrich this molecule from the leaf powder and to extract it in suitable medium. The technology package has been up scaled and passed on to M/S Genova Biotechniques, Hyderabad on consultancy basis. The company has set up a production Unit in Hyderabad based on the technical know how of RRL and has also tied up with M/S Ochoa Pharmaceuticals for marketing the product under their brand name.
Pharmacological data of a herbal formulation as dietary/food supplement : In a record time of 7 months RRL, Jammu has completed t oxicity studies as per USFDA/OECD Guidelines and preclinical studies for generating pharmacological data on a herbal formulation as a dietary / food supplement for sexual behaviour changes. The Technical Report along with the Video Film on the efficacy of formulation on animals as aphrodisiac has been passed on to M/S Flex Foods Ltd., Dehradun.
Herbal formulation as hepatoprotective being licensed : 
RRL, Jammu after the years of dedicated work has developed a single herb formulation as hepatoprotective against alcoholic and viral cirrhosis. The product is standardized based on two identified chemical markers. The formulation is being licensed to M/S Madley Pharmaceuticals Ltd., Mumbai at a total consultancy fee of Rs 29.00 lakhs as per the agreement entered on 14 th June, 2003 . The company after conducting the proof of concept in humans have finally launched the product as LIV-1 in both tablet and syrup form.
New Research Projects in Pipeline
Major projects with world renowned pharmaceutical companies under mentioned have either been finalized or are under negotiations.
Proctor & Gamble Worldwide, USA
M/S INDIGENE Pharmaceuticals Pvt. Ltd.
M/S Ochoa Laboratory, Ltd., New Delhi
M/S Zandu Pharmaceuticals, Mumbai
M/S Nicholas Primal India , Mumbai
Engineering Design capabilities:
Multipurpose herbal extraction pilot Plant for Malaysia :
M/S Tropical Botanics SDN BHD, Malaysia has retained RRL, Jammu as consultant to undertake design, drawing, installation, commissioning, validation and testing of multipurpose herbal extraction pilot Plant in Malaysia . For this RRL, Jammu would also help the party in short listing the appropriate fabricator in India and also to demonstrate the working of the plant for processing herbals / botanicals both in India and Malaysia .Based on the performance of the pilot plant, the company intends to retain RRL as their consultant for the designing of the production Plant as well.
Solvent Extraction unit for Herbs:
A multi-functional solvent extraction unit was designed & fabricated in house for the production of herbal extracts. The capacity of this unit is 15 Kg per batch. Currently it is being used for the production of standardized extracts of several medicinal plants cultivated in the demonstration fields at RRL, Jammu and Srinagar .
Multi-functional pilot scale fermentor: 
A microprocessor controlled 75 to 100 liter fermentor with all required process controls was designed by Dr. G. N. Qazi and his group and fabricated under the guidance of RRL by M/S Andel Industries, Mohali. The pilot plant has been successfully installed and commissioned at a number of places under consultancy programme. The total cost of the each such unit is approximately Rs. 1.5 million. The plant has all the features of an R&D pilot scale fermentor wherein distributed parameters and variables can be studied. It can also be used as a production plant for high-value low-volume products, even for genetically engineered organisms.
Production Plant for D-gluconates:
A single step fermentation process wherein starch hydrolysate is directly converted to gluconates of Calcium, Sodium, Barium etc. has been developed. The process has the advantage over the existing methods for being highly cost effective less energy intensive and environmental friendly. The gluconate salts are used in neutraceuticals, human and veterinary pharmaceuticals, food and cosmetic industry. The technology has been transferred to M/S Prathistha Industries Ltd., Hyderabad and a Production plant of 1500 tonnes per annum capacity already been commissioned. In recognition of this achievement the Institute was awarded CSIR Technology Award 2001, Vasvik Award 2000 and 64 th All India Industrial Award 2004 for this technology package.
Production Plant for Bio fertilizers & Bi control agents :
Based on RRL technology, M/S Prathistha Industries Ltd., Hyderabad commissioned a Production Unit for the production of bio fertilizers and bio control agents on 11 th May, 2004 . The products like bio potash and bio zinc are already being marketed by the company throughout the country.
Micropropagation protocols developed:
In vitro propagation and conservation of Atropa acuminata Royle ex Lindl.
A tissue culture procedure has been developed for multiplication and conservation of Atropa acuminata Royle. ex Lindl. by induction of axillary shoot proliferation. In vitro raised plantlets were hardened and successfully transferred to field.
Micro-propagation of Hypericum perforatum : 
Rapid in vitro and ex vitro micropropagation protocols have been developed at RRL, Jammu for mass propagation of the chemically identified 'elite' strains of Hypericum perforatum collected from the wild sources. More than one lakh plantlets developed through above protocol have been successfully raised in the experimental farms of RRL Branch, Srinagar .
Micro-propagation of Hedychium spicatum :
Rapid in vitro micropropagation protocol has been developed at RRL, Jammu for mass propagation of the chemically identified 'elite' strains of Hedychium spicatum collected from the Darjeeling Hills. Greenhouse hardened plants were transferred to field. A successful protocol with 99% root formation and 80–85% field survival has been developed.
Micro-propagation of Celastrus paniculatus :
Regional Research Laboratory, Jammu has developed the complete protocol to regenerate C. paniculatus by culturing excised embryos via organogenesis on the standardized selective conditions and sequence of media. The developed procedure can be adopted for large scale propagation and conservation of this medicinally important plant species which otherwise figured as threatened.
Micro-propagation of Lavendulla officinalis : 
Protocol or efficient regeneration system through forced axillary bud induction and organogenesis in Lavendulla officinalis an important aromatic plant has been developed and standardized.
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Indian Institute of Integrative Medicine,Jammu (formerly known as Regional Research Laboratory)
